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Direct oral anticoagulant and AKI: apixaban-induced acute interstitial nephritis


Direct oral anticoagulants (DOACs)—dabigatran, rivaroxaban, apixaban and edoxaban—are changing the landscape of clinical practice for patients requiring short and long-term anticoagulation. We report a patient with no history of kidney disease developing acute interstitial nephritis (AIN) after starting a DOAC, apixaban. To date, this is the first biopsy proven case of apixaban-induced AIN.

  • acute renal failure
  • haematology (drugs and medicines)
  • renal system
  • haematology (incl blood transfusion)

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