Direct oral anticoagulants (DOACs)—dabigatran, rivaroxaban, apixaban and edoxaban—are changing the landscape of clinical practice for patients requiring short and long-term anticoagulation. We report a patient with no history of kidney disease developing acute interstitial nephritis (AIN) after starting a DOAC, apixaban. To date, this is the first biopsy proven case of apixaban-induced AIN.
- acute renal failure
- haematology (drugs and medicines)
- renal system
- haematology (incl blood transfusion)
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Contributors CD: conceived the need to write this case, completed the literature review and drafted the report. WH and JM: completed the critical revision of the report. Final approval of the version to be published was given by JR.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Obtained.