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Acquired amegakaryocytic thrombocytopenia as a rare cause of thrombocytopenia during pregnancy
  1. Brittney S Zimmerman1,
  2. Bridget Marcellino1,
  3. Siraj M El Jamal2 and
  4. Anne S Renteria3
  1. 1 Department of Hematology Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  2. 2 Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  3. 3 Hematology Oncology - BMT Department, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  1. Correspondence to Dr Anne S Renteria, anne.renteria{at}, asrdeazevedo{at}


A rare case of acquired amegakaryocytic thrombocytopenia (AATP) in a 35-year-old woman who presented with anaemia and thrombocytopenia at 22 weeks gestation. The first diagnostic impression was of an evolving aplastic anaemia; however, the patient was simultaneously diagnosed with severe vitamin B12 deficiency in the setting of vegetarianism. Once the cyanocobalamin deficiency was corrected, a repeat bone marrow biopsy revealed an isolated depletion of megakaryocytes, which suggested the diagnosis of AATP. Supportive care was provided for her anaemia and thrombocytopenia and she delivered a healthy baby girl with a normal platelet count. The patient was subsequently started on romiplostim with steady improvement in her platelet counts. This rare AATP case presentation highlights the importance of a well-structured diagnostic approach to thrombocytopenia during pregnancy and supports the successful use of thrombopoietin agonists for the management of AATP.

  • haematology (incl blood transfusion)
  • obstetrics and gynaecology
  • pregnancy
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  • Contributors BSZ and BM are haematology/oncology fellows, SMEJ is a clinical pathologist and ASR is a haematology/oncology attending and they all contributed to caring for this patient as well as the conception, preparation, writing and reviewing of the case report. SMEJ was responsible for reviewing the patient’s bone marrow biopsy pathology specimen. All authors approved the final manuscript and contributed substantially to its preparation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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