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Carcinosarcoma prostate with osteosarcomatous differentiation: a rare de novo presentation
  1. Sumeet Aggarwal1,
  2. Swarupa Mitra1,
  3. Abhinav Dewan1 and
  4. Garima Durga2
  1. 1 Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India
  2. 2 Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India
  1. Correspondence to Dr Swarupa Mitra, swarupamitra{at}


Carcinosarcoma is a rare histological event in the history of prostatic malignancies. Historically aggressive tumours with dismal outcomes reported in scarce literature available so far. Very few recent studies suggest good outcomes with modern era surgery and radiotherapy techniques in localised disease. The case presented here had no history of known risk factors like prior adenocarcinoma or prior radiation therapy. This case presented with obstructive urinary symptoms with no prostate-specific antigen elevation, diagnosed with imaging, managed aggressively with robotic surgery. Detailed immunohistochemistry and pathological review suggested diagnosis as carcinosarcoma with osteosarcomatous differentiation. Very rare such cases were reported in the past with complete clinical, radiological, pathological details and managed aggressively with good outcomes. The patient is disease free after 6 months of follow-up.

  • urological cancer
  • prostate
  • urological surgery
  • prostate cancer
  • radiotherapy

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  • Contributors SA has written the manuscript. SM had provided critical case details and proof read the article. AD has provided language help and writing assistance. GD had provided pathological details and helped in manuscript writing and proof reading.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.