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Rare case of Bing-Neel syndrome treated successfully with ibrutinib
  1. Hamza Hashmi1,
  2. Jugraj Singh Dhanoa2 and
  3. Robert Emmons3
  1. 1 Hematology Oncology, University of Louisville, Louisville, Kentucky, USA
  2. 2 Internal Medicine, University of Louisville, Louisville, Kentucky, USA
  3. 3 Blood and Marrow Transplant, University of Louisville School of Medicine, Louisville, Kentucky, USA
  1. Correspondence to Dr Hamza Hashmi, hamzahashmi87{at}


Waldenstrom’s macroglobulinaemia (WM) is a lymphoproliferative disorder of the B cell origin. It is characterised by the presence of IgM paraprotein in the serum and lymphoplasmacytic lymphoma cells in the bone marrow with extranodal involvement relatively uncommon. Bing-Neel syndrome (BNS) is a neurological complication of WM that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells. We present an interesting case of BNS that responded remarkably to ibrutinib monotherapy.

  • haematology (incl blood transfusion)
  • medical management
  • chemotherapy
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  • Contributors HH, as the primary author of this manuscript, had a large role in writing the manuscript, specifically in acquiring data from the most relevant studies and incorporating such data into the manuscript to support and/or refute our arguments in to be as objective as possible. JSD played an important role in the conception, design and construction of this manuscript, including selecting which content to highlight, use of proper research language. He also played a small role in data interpretation. RE played a supervisory role as the project’s principal investigator, and oversaw the interpretation and analysis of collected data. He was also essential in connecting the current literature to our own patient’s case, which resulted in effective translational care for the patient and for communication of ideas and learning through the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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