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Transient splenial lesion due to non-cirrhotic hyperammonaemia in dengue fever
  1. Robin George Manappallil1,
  2. Sunil V Nair2,
  3. Aryashree Kakkattil1 and
  4. Blessy Josphine1
  1. 1 Department of Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India
  2. 2 Department of Radio Diagnosis and Imaging, Baby Memorial Hospital, Calicut, Kerala, India
  1. Correspondence to Dr Robin George Manappallil, drrobingeorgempl{at}


Transient splenial lesion(TSL) is seen in a variety of conditions and is detectable only on MRI of the brain. Dengue fever (DF) is a common viral infection encountered in the tropics. The affected patients may face neurological complications like encephalopathy and intracranial haemorrhage, or even ischaemic stroke. Non-cirrhotic hyperammonaemia is a rare scenario; and its occurrence in DF is unknown. The patient being described had DF and developed dysarthria. His MRI brain showed splenial hyperintensity. Further evaluation revealed non-cirrhotic hyperammonaemia. To the best of our knowledge, TSL due to non-cirrhotic hyperammonaemia in DF is an unreported scenario.

  • Dengue fever
  • hyperammonemia
  • transient spenial lesion

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  • Contributors RGM: concept and design, manuscript preparation, revision of manuscript and treating physician. SVN: critical revision of manuscript and radiologist. AK: resident in-charge. BJ: resident in-charge.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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