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Comparison of two patients presenting with the clear cell variant of urothelial cell carcinoma of the urinary bladder: laser-assisted partial cystectomy for local disease versus chemotherapy for locally advanced disease
  1. James P Blackmur1,2,
  2. Nadja Melquiot3,
  3. Katherine E Robertson3 and
  4. Seamus Teahan2
  1. 1 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
  2. 2 Urology Department, NHS Forth Valley, Larbert, UK
  3. 3 Histopathology Department, NHS Forth Valley, Larbert, UK
  1. Correspondence to Mr James P Blackmur, jamesblackmur{at}


A 43-year-old woman and a 73-year-old man were referred separately from primary care to the urology service with short histories of frank haematuria. In both cases, histology from transurethral resection of their bladder tumours demonstrated the rare clear cell variant of urothelial/transitional cell carcinoma. Staging scans found the former patient had low-volume local disease, and the latter had locally advanced disease. The former patient went on to have partial cystectomy and pelvic lymph node dissection (with the endoscopic portion of the partial cystectomy undertaken by holmium:YAG laser), while the latter was found to have inoperable disease, and proceeded to chemotherapy. The former patient was alive with no evidence of disease recurrence at 45 months, while the latter was alive but with extensive lymph nodal recurrence at 45 months.

  • cancer intervention
  • haematuria
  • surgical oncology
  • urological cancer
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  • Contributors JPB was involved in patient care, diagnosis, patient consent and drafting the manuscript. NM and KER were involved in diagnosis, management decisions and editing the manuscript. ST was involved in patient diagnosis, management and edited the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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