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Eosinophilic granulomatosis with polyangiitis in a Nigerian woman
  1. Ngozi Lina Ekeigwe1,
  2. Olufemi Adelowo2,
  3. Ehiaghe Lonia Anaba2 and
  4. Hakeem Olaosebikan2
  1. 1 Department of Internal Medicine, Federal Medical Center Owerri, Owerri, Nigeria
  2. 2 Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria
  1. Correspondence to Professor Olufemi Adelowo, femiadelowo2003{at}


Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss Syndrome, is a systemic autoimmune disease that is usually associated with asthma and eosinophilia. It is a rare condition associated with antineutrophil cytoplasmic antibodies (ANCA). We report a case of a 52-year-old Nigerian woman who presented with bilateral leg swelling with multiple ulcers, background history of allergic rhinitis and chronic sinusitis since adolescence. There were also associated symptoms of peripheral neuropathy, weight loss, peripheral blood eosinophilia and positive perinuclear ANCA and she was previously managed for rheumatoid arthritis and asthma. She fulfilled the American College of Rheumatology criteria for EGPA and was treated with glucocorticoids and methotrexate which led to significant improvement of her symptoms.

  • vasculitis
  • asthma
  • peripheral nerve disease
  • dermatology
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  • Contributors OA conceived the idea to write the case report. NLE wrote the report. OA and HO edited the report. ELA carried out and reported the histology. Every member of the team managed the patient and approved the final version of the report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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