Article Text

Download PDFPDF
Primary angiosarcoma of thyroid
  1. Ananya Kondapalli1,
  2. Lucas Redd2,
  3. Lorraine DeBlanche2 and
  4. Yin Oo2
  1. 1 Department of Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  2. 2 VA North Texas Health Care System, Dallas, Texas, USA
  1. Correspondence to Dr Yin Oo, yinhtweo{at}


Mesenchymal origin of primary thyroid angiosarcomas (TAS) is extremely rare and comprises less than 1% of primary thyroid cancer worldwide. While TAS are most commonly occurring in the Alpine region, there are multiple reported cases of TAS in non-Alpine regions. Diagnosis of TAS is commonly made after thyroidectomy as cytologic diagnosis can be challenging due to paucity of cells, presence of necrosis and unawareness of the disease due to rarity. We report a case of primary TAS diagnosed by cytology in a 56-year-old man who presented with a sudden onset of left neck pain, swelling and haemoptysis. He was later noted to have suspicious nodules on both lobes of thyroid on ultrasound. Fine needle aspiration of thyroid nodules showed malignant epithelioid cells. The diagnosis of TAS was made based on positive endothelial markers such as thrombomodulin and CD31, with many pertinent negatives, including negative cytokeratins,thyroid transcription factor (TTF1), thyroglobulin, calcitonin and carcinoembryonic antigen (CEA).

  • thyroid disease
  • cancer intervention
  • endocrine cancer
View Full Text

Statistics from


  • Contributors All authors contributed equally to this manuscript: discuss planning, conduct, reporting, conception and design, acquisition of data as well as analysis and interpretation of data. AK: data gathering, reviewing and writing. LR: interpretation, data gathering, reviewing and writing. LD: interpretation, data gathering and reviewing. YO: data gathering, interpretation, writing and reviewing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.