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Unexpected benefit from an ‘old’ metronomic chemotherapy regimen in advanced chordoma
  1. Mariella Spalato Ceruso,
  2. Andrea Napolitano,
  3. Marianna Silletta and
  4. Bruno Vincenzi
  1. Medical Oncology, Universita Campus Bio-Medico di Roma, Roma, Lazio, Italy
  1. Correspondence to Professor Bruno Vincenzi, b.vincenzi{at}


In this case report, we describe an older adult man affected by advanced chordoma progressing after treatment with cisplatin and imatinib. The patient was symptomatic for uncontrolled pain. We decided to treat the patient with metronomic cyclophosphamide, unexpectedly achieving long-lasting clinical and radiological benefit.

  • oncology
  • chemotherapy
  • geriatric medicine
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  • Contributors MSC: case report conception, data collection and manuscript drafting. AN: data collection and figure preparation. MS: data collection. BV: final revision and editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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