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Myoclonic status epilepticus induced by cefepime overdose requiring haemodialysis


We report a case of cefepime neurotoxicity characterised by myoclonic status epilepticus with coma, in a context of acute renal failure and requiring one discontinuous conventional haemodialysis. Cefepime is a fourth-generation broad‐spectrum cephalosporin mainly used to treat hospital-acquired Gram-negative infections. Acute neurotoxicity is an increasingly reported adverse effect which occurs predominantly in patients with renal impairment. Renal replacement therapy has been proposed to treat this condition.

  • healthcare improvement and patient safety
  • epilepsy and seizures
  • unwanted effects/adverse reactions
  • dialysis
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