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Two synchronous malignancies: nodular melanoma and renal cell carcinoma in a patient with an underlying germline BRCA2 mutation
  1. Anson Snow1,
  2. Charite Ricker2 and
  3. Gino K In3
  1. 1 Department of Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
  2. 2 Department of Medicine, Division of Medical Oncology, University of Southern California - Norris Comprehensive Cancer Center, Los Angeles, California, USA
  3. 3 Department of Dermatology, University of Southern California - Keck School of Medicine, Los Angeles, California, USA
  1. Correspondence to Dr Gino K In,{at}


Modernised genetic testing among patients with cancer has led to an increasing wealth of knowledge regarding cancer biology and aetiology. Furthermore, some germline mutations have the potential to direct therapeutic approaches as well. While BRCA1/2 mutations are well-established risk factors for breast and ovarian cancers, their impact on other cancers is less understood. We describe a patient with a germline BRCA2 mutation who developed synchronous melanoma and renal cell carcinoma, but responded well to treatment and is now cancer free.

  • oncology
  • skin cancer
  • urological cancer
  • genetics

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  • Contributors GKI conceived of the case report concept. GKI, AS, and CR contributed to the writing of the case report. All authors contributed to the refinement of the case report and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.