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Respiratory symptoms in a child with IgE-non-dependent hypersensitivity to wheat
  1. Federica Sullo,
  2. Giuseppe Fabio Parisi,
  3. Annarita Bongiovanni and
  4. Salvatore Leonardi
  1. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
  1. Correspondence to Dr Giuseppe Fabio Parisi, giuseppeparisi88{at}


Food allergy (FA) is a serious health problem, and its incidence has been increasing especially in children. Wheat is one of the five most common foods that trigger allergic reactions in children. It is an increasingly recognised trigger for immune-mediated FAs, both Immunoglobulin E (IgE) and non-IgE mediated. We describe the case of a 4-year-old boy with a combination of symptoms due to IgE-mediated asthma worsened by IgE-non-dependent hypersensitivity to wheat demonstrated by a positive patch test. With the avoidance of wheat oral intake, we observed a progressive clinical improvement. To the best of our knowledge, this is the first report of a patient with IgE-non-dependent allergy to wheat presenting with chronic symptoms in one body system outside of the gastrointestinal tract and with negative skin prick test.

  • paediatrics
  • childhood nutrition (paediatrics)
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  • Contributors FS, GFP and AB followed the patient from the diagnosis to the therapy. FS and GFP wrote the manuscript. SL coordinated the group and revised critically the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Parental/guardian consent obtained.

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