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Pfeifer-Weber-Christian disease and successful treatment with mycophenolate mofetil: a case report
  1. Subash Somalanka1,
  2. Ini Udo2,
  3. Hari Nair3 and
  4. Shashidhar Baikunje4
  1. 1 South West Thames Renal & Transplantation Unit and South West Thames Institute for Renal Research, Saint Helier Hospital, Carshalton, Surrey, UK
  2. 2 General Medicine, Portsmouth Hospitals NHS Trust, Portsmouth, UK
  3. 3 Renal Medicine, Glan Clwyd Hospital, Rhyl, Denbighshire, UK
  4. 4 Department of General Medicine, Singhealth, Singapore
  1. Correspondence to Dr Subash Somalanka, Nephr0nite{at}


Inflammatory conditions manifest with a broad spectrum of signs and symptoms. Panniculitis is such a condition affecting the subcutaneous fat and presents as tender erythematous nodules. It is also associated with a systemic response and has been described in the literature as early as in 1892 by Pfeifer and in the 1920s by Weber and Christian. We present an unusual case of a Caucasian man with recurrent febrile illness, systemic inflammatory response and renal dysfunction requiring acute high dependency care. The authors successfully treated him with an antiproliferative agent, mycophenolate mofetil, which resulted in preventing him from having further episodes.

  • immunology
  • pathology
  • acute renal failure
  • dermatology
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  • Contributors SS prepared the manuscript and looked after the patient. IU contributed to the manuscript. HN and SB contributed to the manuscript and looked after the patient.

  • Funding The authors did not receive any specific grant or support for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

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