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Endobronchial, laryngeal and mediastinal melanoma: a rare constellation of metastatic disease
  1. Grace Nabila Martinez Pena and
  2. Chuan Jiang
  1. Medicine – Pulmonary Medicine, Jamaica Hospital Medical Center, Jamaica, New York, USA
  1. Correspondence to Dr Chuan Jiang, cjiangmd{at}


A 45-year-old man presents with acute respiratory failure. Imaging revealed a left mainstem endobronchial mass with subcarinal lymphadenopathy, but no other evidence of a primary tumour. An incidental laryngeal nodule was found during bronchoscopy. Biopsies of this lesion by nasopharyngoscopy and subcarinal lymph nodes via mediastinoscopy were performed. Histopathological and immunohistochemical examination showed evidence of melanoma in both samples. Mutational analysis identified the presence of a BRAFV600E mutation. The patient underwent bronchoscopic ablation of the left mainstem endobronchial tumour with laser therapy followed by initiation of encorafenib and binimetinib combination therapy. The patient remains alive at 4 months after initial presentation of disease. This case adds to the body of literature highlighting the clinical heterogeneity and challenges of the management of metastatic pulmonary melanoma. To the best of our knowledge, this simultaneous constellation of metastasis has not been described before.

  • cancer intervention
  • respiratory medicine
  • lung cancer (oncology)
  • skin cancer
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  • Contributors GNMP and CJ both contributed to the creation and writing of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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