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Henoch-Schonlein purpura associated with HLA-B27 positive axial spondyloarthritis in a young man
  1. Kevin John John1,
  2. Mohammad Sadiq1,
  3. Meera Thomas2 and
  4. Vijay Prakash Turaka1
  1. 1 Department of Internal Medicine, Christian Medical College, Vellore, Tamil Nadu, India
  2. 2 Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India
  1. Correspondence to Dr Kevin John John, kevinjohn619{at}


Axial spondyloarthropathies are characterised by bilateral sacroiliitis, asymmetric oligoarthritis, association with the human leucocyte antigen (HLA)-B27, enthesitis and dactylitis. Although IgA nephropathy has a well-documented association with seronegative spondyloarthropathies, the association with Henoch-Schonlein purpura (HSP) has been documented only in few case reports. The present case is that of a 26-year-old man who presented with fever, lower limb arthritis, abdominal pain, palpable purpura over the buttocks and lower limbs, and clinical features of sacroiliitis. His blood tests showed elevated inflammatory markers and rheumatoid factor was negative. CT scan of the sacroiliac joints confirmed sacroiliitis. Skin biopsy revealed neutrophilic small vessel vasculitis. HLA-B27 was positive in blood. A diagnosis of HSP with HLA-B27 positive axial spondyloarthritis was made. HSP can be associated with HLA-B27 positive axial spondyloarthritis and has to be considered while evaluating for causes of cutaneous small vessel vasculitis in such patients.

  • dermatology
  • musculoskeletal and joint disorders
  • skin
  • anklosing spondylitis
  • vasculitis

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  • Contributors KJJ conceived, designed and drafted the manuscript. MS was the junior consultant and VPT the senior consultant involved in patient care. Both MS and VPT reviewed the manuscript. MT was the pathologist who reported the biopsy.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed

  • Patient consent for publication Obtained.