Article Text

Download PDFPDF
Severe peripheral oedema as the only presenting symptom of intravascular large B-cell lymphoma: a diagnosis too frequently made on autopsy
  1. Rachel Kyle1,
  2. Gillian Mount2,
  3. Shao Shi Li3 and
  4. Jenny Thain1
  1. 1 Department of Medicine, Division of Geriatric Medicine, London Health Sciences Centre, London, Ontario, Canada
  2. 2 Department of Medicine, Division of Hematology, London Health Sciences Centre, London, Ontario, Canada
  3. 3 Department of Pathology, London Health Sciences Centre, London, Ontario, Canada
  1. Correspondence to Dr Jenny Thain, jenny.thain{at}


Intravascular large B-cell lymphoma is seen in less than one per million people and can be an extremely difficult antemortem diagnosis to make due to a vast diversity of presenting symptoms. We present a case of an otherwise healthy 74-year-old woman whose predominant symptom was pitting oedema, and who likely died from multiorgan failure after >14 months of extensive workup that was unable to secure a definitive diagnosis.

  • geriatric medicine
  • malignant and benign haematology
  • pathology
View Full Text

Statistics from


  • Handling editor Seema Biswas

  • Contributors RK prepared the manuscript. GM provided haematological expertise and assisted in manuscript preparation. SSL provided expertise with regards to the pathology findings and provided pathology images. JT oversaw preparation of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.