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Permanent central diabetes insipidus after mild head injury
  1. Ersen Karakilic1 and
  2. Serhat Ahci2
  1. 1 Endocrinology and Metabolism, Canakkale Onsekiz Mart Universitesi Tip Fakultesi, Canakkale, Turkey
  2. 2 Internal Medicine, Canakkale Onsekiz Mart Universitesi Tip Fakultesi, Canakkale, Turkey
  1. Correspondence to Dr Ersen Karakilic, ersenkarakilic{at}


We report a case of a patient with mild traumatic brain injury (TBI) who was diagnosed with permanent central diabetes insipidus (DI). A 21-year-old man was admitted to our outpatient clinic with polyuria and polydipsia 1 week after a mild head injury. He was well, except for these complaints. The initial laboratory workup was consistent with DI. There was no abnormality with other laboratory and hormone values. MRI showed lack of neurohypophyseal hyperintensity with no other abnormal findings. The patient responded well to desmopressin therapy. At the first year of the diagnosis, the patient still needed to use desmopressin treatment as we concluded that DI is permanent. DI is not uncommon after TBI, but it is often seen after severe TBI. We present here an extraordinary case of developing permanent DI after mild TBI with the absence of neurohypophyseal bright spot on MRI with no other abnormal findings.

  • pituitary disorders
  • neurological injury
  • neuroendocrinology
  • trauma Cns /pns

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  • Contributors Diagnosis and treatment of the patient were performed together by EK and SA. The case report of the patient was written by EK and SA together.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.