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Xanthoma disseminatum with neurological involvement and optic atrophy: improvement with cladribine
  1. Suman Patra,
  2. Saurabh Bhatia,
  3. Binod K Khaitan and
  4. Neetu Bhari
  1. Dermatology and Venereology, AIIMS, New Delhi, India
  1. Correspondence to Dr Neetu Bhari, drntbhari{at}


A 9-year-old boy presented with multiple hyperpigmented papules over flexors with polyuria, polydipsia and progressive loss of vision. Histopathology of papule suggested a diagnosis of non-Langerhans cell histiocytosis and systemic evaluation showed central diabetes insipidus and optic atrophy. With a diagnosis of xanthoma disseminatum with significant neurological involvement, he received cladribine therapy and showed significant improvement in both cutaneous and nervous system lesions.

  • dermatology
  • paediatrics
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  • Contributors SP, SB, BKK and NB prepared, reviewed and finalised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Parental/Guardian consent obtained.

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