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Treatment failure with propranolol for subglottic haemangioma
  1. Zhaobo Liu1,
  2. Yen Huan Yeo2,
  3. Conor Jackson3 and
  4. Keith Trimble3
  1. 1 Nottingham University Hospitals NHS Trust, Nottingham, UK
  2. 2 Queen’s University Belfast, Belfast, UK
  3. 3 Royal Belfast Hospital for Sick Children, Belfast, UK
  1. Correspondence to Dr Zhaobo Liu, paulliuzb{at}


The use of propranolol for the treatment of subglottic haemangioma has become hugely popular due to its effectiveness and safety profile. We report a case of 7-month-old boy who presented with stridor and histopathology suggestive of subglottic haemangioma following microlaryngoscopy and bronchoscopy (MLB). However, he did not respond to propranolol treatment. This could be due to an older age of propranolol commencement. In general, early commencement of propranolol is necessary when diagnosis of symptomatic infantile haemangioma is made to achieve maximal improvement in symptoms and prevent further proliferation. There should be a high index of suspicion for subglottic haemangioma in children presenting with chronic biphasic stridor, with early MLB and diagnosis. This will allow early treatment, giving the best chance to avoid our situation.

  • ear, nose and throat
  • congenital disorders
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  • Contributors ZL: manuscript preparation and editing. YHY: manuscript preparation and editing. CJ: manuscript editing and operating surgeon. KT: manuscript editing, operating surgeon and supervisor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

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