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Non-infectious aortic and mitral valve vegetations in a patient with eosinophilic granulomatosis with polyangiitis
  1. Kamalesh Karthikeyan1,
  2. Sudarshan Balla2 and
  3. Martin A Alpert3
  1. 1 University of Missouri-Columbia, Columbia, Missouri, USA
  2. 2 Cardiology, University of Missouri Health Care, Columbia, Missouri, USA
  3. 3 Cardiology, University of Missouri-Columbia, Columbia, Missouri, USA
  1. Correspondence to Dr Kamalesh Karthikeyan, kamalaysh{at}


Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of vasculitis characterised by atopic manifestations, inflammation of small-sized to medium-sized arteries and veins, hypereosinophilia and tissue infiltration with eosinophils. Cardiac complications occur most commonly in the absence of antineutrophil cytoplasmic antibodies. Cardiac complications include coronary arteritis (rare), pericarditis, myocarditis, endocardial fibrosis (Loeffler’s endocarditis) and intracavitary thrombosis of the left or right ventricle. This is the first reported case of large non-infectious valvular vegetations associated with EGPA.

  • cardiovascular medicine
  • valvar diseases
  • immunology
  • pathology
  • vasculitis

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  • Contributors KK involved with writing up the clinic case and gathering the data for case reporting. Drafting and editing the case report to final form. SB and MAA involved in the conception, planning and analysis, and interpretation of the data. Involved in providing insight into format for write-up and data presentation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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