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Jaundice and anaemia as presenting features of an incomplete autoimmune polyglandular syndrome type II
  1. Mainak Banerjee1,
  2. Sumit Kumar Mondal2,
  3. Indira Maisnam3 and
  4. Apurba Kumar Mukherjee2
  1. 1 Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research, Kolkata, India
  2. 2 Department of General Medicine, R.G. Kar Medical College and Hospital, Kolkata, India
  3. 3 Department of Endocrinology, R.G. Kar Medical College and Hospital, Kolkata, India
  1. Correspondence to Dr Mainak Banerjee, mainak18y{at}


The coexistence of adrenal failure with either autoimmune thyroid disease and/or type 1 diabetes is defined as autoimmune polyglandular syndrome (APS) type 2 or Schmidt’s syndrome. Vitiligo, hypergonadotropic hypogonadism, chronic autoimmune hepatitis, alopecia, pernicious anaemia and seronegative arthritis may also be present. We present a case of 45-year-old Indian man with progressive jaundice and asthenia for 3 months. He was also found to have pallor, icterus, dry coarse skin and delayed relaxation of ankle jerk. Investigations showed pancytopaenia with megaloblastic changes due to pernicious anaemia, autoimmune hypothyroidism and autoimmune adrenalitis with evolving adrenal insufficiency. Upper gastrointestinal endoscopy guided biopsy showed evidence of gastric mucosal atrophy. Patient responded well to hydroxocobalamin and thyroxine replacement. Detailed workup to check for evolving APS II is prudent in a hypothyroid patient presenting with pallor and jaundice. It may alert physicians to possible adrenal crisis in the future, especially after starting levothyroxine replacement in these patients.

  • endocrinology
  • adrenal disorders
  • thyroid disease

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  • Contributors MB, SKM, IM and AKM were actively involved in managing this case from the very beginning and MB wrote the final case report as corresponding author. IM and AKM guided him through management of this case as well as the process of writing the case report on an interesting presentation of rather a common endocrine problem, often missed early in its course.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.