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Disseminated Cryptococcus neoformans infection in a left ventricular assist device recipient
  1. Deeksha Jandhyala1,2,
  2. Eugene M Tan2,
  3. David Cook Stahr3 and
  4. Muhammad Rizwan Sohail4
  1. 1 Internal Medicine, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
  2. 2 Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
  3. 3 Oral and Maxillofacial Surgery, West Virginia University, Morgantown, West Virginia, USA
  4. 4 ID, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Deeksha Jandhyala, sohail.muhammad{at} and Dr Muhammad Rizwan Sohail, sohail.muhammad{at}


A 51-year-old man with a medical history of coronary artery disease and dyslipidaemia presented with acute myocardial infarction resulting in cardiogenic shock, necessitating intra-aortic balloon pump placement and extracorporeal membrane oxygenation (ECMO). His hospital course was complicated by several infectious complications including ECMO circuit Pseudomonas aeruginosa bloodstream infection and presumed infected right atrial thrombus. He subsequently underwent urgent left ventricular assist device placement and had a prolonged hospital stay. On day 100 of admission, he developed acute hypoxic respiratory distress with new pulmonary infiltrates. Sputum cultures grew Cryptococcus neoformans. Blood culture also grew C. neoformans after 96 hours of incubation and cryptococcal serum antigen was elevated at 1:20. Cerebrospinal fluid studies from a lumbar puncture were normal. He was treated with 2 weeks of combination antifungal therapy followed by life-long fluconazole suppression.

  • cryptococcosis
  • cryptococcus
  • infectious diseases
  • cardiovascular medicine
  • heart failure
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  • Contributors DJ wrote the main manuscript including major edits. EMT obtained patient consent, edited imaging and reviewed literature. DCS was primarily involved in literature review and provided expertise on tracheostomy technique and infection risk. MRS is the attending mentor for this case.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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