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Dental management of patients with haemophilia in the era of recombinant treatments: increased efficacy and decreased clinical risk
  1. Antonio Liras and
  2. Luis Romeu
  1. Universidad Complutense de Madrid, Madrid, Spain
  1. Correspondence to Professor Antonio Liras, aliras{at}


Haemophilia is a hereditary X-linked recessive disorder caused by a deficiency of either clotting factor VIII (haemophilia A) or IX (haemophilia B). Conventional treatment is currently based on the use of either plasma derived or recombinant coagulation factors. This paper reports on the case of a patient with severe haemophilia who presented with mesial decay and interproximal tartar build-up, for which extraction and scaling to remove tartar deposits were indicated. Following extraction, the usual haemostasis techniques were applied, and postoperative prophylactic antihaemophilic treatment was indicated for 2 or 3 days. The patient presented with moderate bleeding for a few minutes immediately after the procedure. Administration of factor VIII before surgery as well as the patient’s favourable pharmacokinetic response allowed for an optimal result. This treatment has afforded patients with haemophilia a better quality of life, and safe and efficient access to invasive surgical procedures.

  • haematology (incl blood transfusion)
  • dentistry and oral medicine
  • pharmacology and therapeutics

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  • Contributors AL and LR conceived and designed the study. AL performed the formal haematological analysis. LR performed the clinical dental procedure. AL wrote the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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