Takotsubo syndrome is an intriguing condition of often stress induced reversible cardiac dysfunction mimicking myocardial infarction, but without explanatory coronary obstructions. The pathogenesis of the syndrome is not yet fully understood, though altered sympathetic regulation or response to cardiac sympathetic stimuli is likely to be involved. We present a unique and clinically detailed report of identical twin sisters, who both developed Takotsubo syndrome in association to mental stress shortly after menopause, also covering a potential relapse of disease in one of the twins, supporting the theory of a genetic contribution to the development of the syndrome proposed by previous case reports and small genetic studies.
- cardiovascular medicine
- heart failure
- radiology (diagnostics)
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Contributors CE is responsible for planning and conducting the case report with acquisition and interpretation of data, collection of medical information about the cases described and obtaining informed patient consents. PT has contributed with conception, planning and design of the case report as well as revision and general knowledge and interpretation of the condition described. JS has contributed with conception, planning and design of the case report as well as revision and general knowledge and interpretation of the condition described.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Obtained.
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