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Robust response to nivolumab in patient with renal cell carcinoma inferior vena cava tumour thrombus
  1. Joel Berends,
  2. Eric Gourley and
  3. Dharam Kaushik
  1. Department of Urology, University of Texas Health, San Antonio, Texas, USA
  1. Correspondence to Dr Dharam Kaushik, kaushik{at}


A 47-year-old previously healthy man presented with acute moderate flank pain. Evaluation revealed left renal cell carcinoma, with inferior vena cava tumour thrombus invasion. Patient had no significant history or risk factors to pre-dispose him to genitourinary cancers. Surgery was deemed to not be appropriate due to distant metastases, but patient received targeted molecular therapy and immunotherapy with striking regression of the thrombus.

  • cancer intervention
  • immunological products and vaccines
  • urology
  • urological surgery

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  • Contributors JB did background research on the case. He contributed to the conception, design of the case report. He drafted the initial project and wrote out the discussion. EG helped review the draft, reviewed imaging and proofread the discussion. He also was in contact with the patient and helped review the outcome and follow up for the patient. DK was the lead on this patient and was lead physician for discussion and recommendations for this patient’s care. He reviewed and approved the final copy for the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.