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IgG4-related disease in a patient with HIV infection
  1. Raquel Ron1,
  2. Ignacio Ruz-Caracuel2,
  3. Eugenia García2 and
  4. María Luisa Montes-Ramírez3
  1. 1 Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
  2. 2 Pathology- IdiPAZ, Hospital Universitario La Paz, Madrid, Spain
  3. 3 Internal Medicine, HIV Unit- IdiPAZ, Hospital Universitario La Paz, Madrid, Spain
  1. Correspondence to Dr Raquel Ron, raquel.rongonzalez{at}


A 47-year-old HIV-positive man with good immune and virological status presented with chronic multiple enlarged lymph nodes, lung disease and eosinophilia. Radiologic tests showed enlarged cervical, thoracic and axillary lymph nodes, with interstitial lung damage. After several non-specific histologic studies, an elevated serum IgG4 level led us to request immunohistochemistry of a lymph node sample. The test confirmed the diagnosis of IgG4-related disease.

  • immunology
  • pathology

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  • Contributors MM-R revised the draft paper and conducted the diagnostic process. IRC and EG analysed and revised the histological samples and contributed to the differential diagnosis and review of literature. RRG wrote the manuscript and reviewed the literature.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.