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Takotsubo cardiomyopathy secondary to haemophagocytic lymphohistiocytosis in HIV patients: a comprehensive review
  1. Waqas Ullah1,
  2. Mohsin Hamid1,
  3. Harshwant Grover1,
  4. Vincent M Figueredo2 and
  5. Faisal Inayat3
  1. 1 Internal Medicine, Abington Hospital - Jefferson Health, Pennsylvania, USA
  2. 2 Cardiology, St Mary Medical Center, Pennsylvania, USA
  3. 3 Internal Medicine, Allama Iqbal Medical College, Lahore, Pakistan
  1. Correspondence to Dr Waqas Ullah, waqasullah.dr{at}


Haemophagocytic lymphohistiocytosis (HLH) is an immune dysregulation disorder with variable presentations and non-specific features making it extremely difficult to diagnose early in the clinical course. Here, we are presenting a case of a young man who presented in cardiogenic shock with findings of anterolateral wall ischaemia on ECG. Echocardiography findings were consistent with takotsubo cardiomyopathy (TCM). Cardiac catheterisation showed clean coronary arteries and pulmonary artery pressure measurements showed high output cardiac failure. After extensive workup, the patient was diagnosed with HLH. In spite of aggressive supportive and definitive therapy, he eventually died due to a complicated clinical course. We did a comprehensive literature review and found that this is the first reported case of HLH presenting as TCM as the initial clinical manifestation.

  • cardiovascular medicine
  • haematology (incl blood transfusion)

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  • Contributors WU and MH did manuscript drafting. HG did revision and did literature review. VMF did supervision and critical review. FI helped in data and review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.