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Glycogenic hepatopathy as a cause of severe deranged liver enzymes in a young patient with type 1 diabetes mellitus
  1. Kalliopi Azariadis1,
  2. Nikolaos K Gatselis1,2,
  3. George K Koukoulis3 and
  4. Georgios N Dalekos1,2
  1. 1 Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece
  2. 2 Institute of Internal Medicine and Hepatology, Larissa, Greece
  3. 3 Department of Pathology, University of Thessaly, Medical School, Larissa, Thessaly, Greece
  1. Correspondence to Professor Georgios N Dalekos, dalekos{at}


Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM). We present a 19-year-old woman with T1DM and autoimmune thyroiditis who admitted to our department because of abrupt onset intermittent abdominal pain in the right upper quadrant accompanied by laboratory evidence of acute anicteric hepatitis. Physical examination revealed significant hepatomegaly but the common imagining studies were negative. Following exclusion of common causes of acute hepatitis and because of the presence of smooth muscle antibodies in a young female patient with already established two autoimmune diseases, a liver biopsy was performed in order to exclude the potential presence of autoimmune hepatitis. However, liver histology showed typical findings of GH. Intense treatment targeting strict glycemic control resulted in normalisation of liver biochemistry. This case underlines that GH should be considered as a rare cause of acute hepatitis in T1DM patients with poor glycemic control.

  • diabetes
  • metabolic disorders
  • hepatitis other
  • pathology

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  • Contributors GND and NKG had the original idea, designed the study and wrote the first draft of the manuscript. KA and NKG collected and summarised the published literature and the data of the patient. GND, KA and NKG were the principal treating physicians, while GKK made the histological diagnosis. GND and GKK made the final critical revision of the manuscript for important intellectual content. All authors have seen and approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.