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CASE REPORT
Chylous ascites in disseminated Kaposi sarcoma: an unusual manifestation as immune reconstitution inflammatory syndrome
  1. Patrícia Cipriano,
  2. Inês Nabais,
  3. Nuno Melo and
  4. Ana Rafaela Alves
  1. Department of Internal Medicine, Hospital de Cascais, Cascais, Portugal
  1. Correspondence to Dr. Patrícia Cipriano, patriciacocipriano{at}gmail.com

Abstract

A 29-year-old man with diarrhoea, fever, abdominal pain and multiple purple papular lesions, neither pruriginous nor painful, was diagnosed with HIV-1 infection and disseminated Kaposi sarcoma (KS) with gastrointestinal involvement. He was started on highly active antiretroviral therapy immediately, as well as doxorubicin. Three weeks later, the patient developed bilateral moderate pleural effusion and large-volume ascites compatible with chylothorax and chylous ascites. An immune reconstitution inflammatory syndrome (IRIS) reaction was assumed. KS flare was associated with lymphatic obstruction and infiltration of thoracic duct by the tumour itself with leakage of chylous into pleural and peritoneal cavities. KS is the most common tumour in HIV patients and the existence of related effusions is not uncommon. KS-related chylothorax is an unusual manifestation of KS; there are only four cases described in the literature of chylous ascites related to KS–HIV. Overall survival is improving in KS but explosive and debilitating IRIS reactions can explain cases with poor prognosis.

  • HIV/aids
  • haematology (incl blood transfusion)
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Footnotes

  • Contributors PC, the corresponding author, and IN were responsible for the conception and drafting of the manuscript, image selection and bibliographic research. NM and ARA were responsible for critical and scientific review. All authors were part of the medical team that made the inaugural diagnosis, approved the paper conception and the final version’s publication.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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