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Hepatosplenic T cell lymphoma presenting as multiorgan failure
  1. Puraskar Pateria1,2,
  2. Annalise Martin3,
  3. Tze Sheng Khor4 and
  4. Vanoo Jayasekeran5
  1. 1 Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
  2. 2 Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
  3. 3 Haematology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
  4. 4 Pathwest Laboratory Medicine, PathWest Laboratory Medicine Western Australia, Nedlands, Western Australia, Australia
  5. 5 Fiona Stanley Hospital, Murdoch, Western Australia, Australia
  1. Correspondence to Dr Puraskar Pateria, puraskar.pateria{at}


A 59-year-oldwoman presented with a 2-month history of malaise, abdominal distention and unintentional weight loss. She was initially managed as community acquired pneumonia with a suspicion of underlying chronic liver disease but she deteriorated rapidly into a multiorgan failure necessitating transfer to intensive care unit of a tertiary hospital. She was investigated with liver and bone marrow biopsy that confirmed the diagnosis of hepatosplenic T cell lymphoma. She was treated with cyclophosphamide, doxorubicin, vincristine, etoposide and prednisolone chemotherapy that was changed to salvage ifosfamide carboplatin etoposide (ICE) chemotherapy due to poor response with first-line chemotherapy and disease progression. Unfortunately, her disease progressed further and she opted for palliative management.

  • chemotherapy
  • carcinogenesis
  • cancer intervention

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  • Contributors All authors have contributed to and have agreed on the content of the manuscript. PP has contributed in obtaining consent from the patient, conceptualising the project and writing the background, case presentation and discussion section of manuscript. AM has contributed in writing the investigation section of the manuscript and provided the PET scan images. TSK contributed in writing discussion section and also, processed and provided the histology sections of the manuscript. VJ has contributed in writing the treatment and discussion section of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.