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Extreme sleep pattern in Lewy body dementia: a hypothalamic matter?
  1. Elisabet Londos1,
  2. Oskar Hansson1,
  3. Ingmar Rosén2 and
  4. Elisabet Englund2
  1. 1 Department of Clinical Sciences Malmö, Lund University, Malmoe, Sweden
  2. 2 Department of Clinical Sciences Lund, Lund University, Lund, Sweden
  1. Correspondence to Professor Elisabet Londos, elisabet.londos{at}


Excessive sleep during the night and for >2 hours during the day is part of the fluctuating wakefulness criterion of dementia with Lewy bodies (DLB). The phenomenon ‘sleep days’ is not uncommon in nursing homes. Here, we describe a woman who, for months, slept for 3 days and nights in a row and thereafter was awake for 3 days and nights. Electroencephalogram (EEG) showed slow background activity and increased delta activity. No epileptiform activity was detected. Polysomnography showed a severely disturbed, markedly fragmented sleep pattern. On her death, neuropathology revealed degeneration and loss of neurons along with α-synuclein-containing Lewy body inclusions and neurites in the substantia nigra, locus coeruleus, hypothalamus, and neocortex, thus fulfilling the criteria of DLB, cortical type. We propose that the hypothalamic degeneration contributed significantly to the clinical profile in this case. We suggest that patients with sleep days should be investigated for other DLB signs.

  • memory disorders
  • sleep disorders (neurology)

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  • Contributors Study concept and design: EYL. Acquisition of data: EYL, EE and IR. Analysis and interpretation of data: EYL, IR, OH and EE. Writing of the manuscript: EYL. Conceptualisation and critical revision of the manuscript for intellectual content: EYL, IR, OH and EE.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.