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Immunodeficiency associated with tumour pathology: Good’s syndrome
  1. Javier Barrios Recio1,
  2. Alejandra Perez Rodriguez2,
  3. Ariel Callero1 and
  4. Juan Antonio Martinez Tadeo1
  1. 1 Department of Allergy, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain
  2. 2 Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain
  1. Correspondence to Dr Ariel Callero, arielcallero{at}


The Good’s syndrome (GS) is a low prevalence entity where thymoma often is associated with immunodeficiency. Patients may start presenting recurrent rhinosinusal infections, bronchopulmonary infections, haematological alterations and diarrhoea, secondary to immunodeficiency. They can also present respiratory symptoms and parathymic syndromes derived from the existence of thymoma, a slow-growing neoplasm located in the anterior mediastinum. We present the case of a 76-year-old man diagnosed with thymoma by image analysis, which had presented multiple episodes of pneumonia and two admissions to the hospital for diarrhoea of weeks of evolution. After finishing the study, the patient is diagnosed of GS. In this case, thymectomy prevented the appearance of parathymic syndrome, but without any effect on immunodeficiency symptoms. To decrease repeat infections, substitution therapy with immunoglobulins was started. The prognosis will depend mainly on the recurrent infectious and to a lesser extent on the thymic neoplasm.

  • oncology
  • immunology
  • malignant disease and immunosuppression

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  • Contributors JBR contributed to conception, design and acquisition of data. APR contributed to discuss planning and conception and design. JAMT contributed to reporting case and acquisition of data. ACV contributed to analysis and interpretation of data.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.