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Anaphylaxis probably induced by transfer of amoxicillin via oral sex
  1. Nazaret Gómez Caballero1,
  2. Susana Almenara2,
  3. Antonia Tévar Terol1 and
  4. José Francisco Horga de la Parte2
  1. 1 Department of Primary Care, Hospital General Universitari d’Alacant, Alicante, Spain
  2. 2 Department of Clinical Pharmacology, Hospital General Universitari d’Alacant, Alicante, Spain
  1. Correspondence to Susana Almenara, susanaalmenara{at}


We present a case of a possible amoxicillin-induced anaphylaxis in a sensitive woman triggered by an instance of oral sexual contact with a man who was taking amoxicillin-clavulanic acid treatment.

To our knowledge, this is the first case reported of a suspicion of amoxicillin-induced anaphylaxis in a woman after a sexual contact with a man who was taking the drug, we hypothesised an oral drug transfer through semen.

Studies about amoxicillin concentrations achieved in semen after a drug intake are scarce. There are few cases reported of hypersensitivity reactions induced by drugs transported in semen but we have found some concern in sensitive patients about the possibility of transference of allergens via sexual intercourse. As clinicians, we consider that it is important to be aware of the existence of this possibility both in the diagnosis and in the prevention of anaphylactic reactions.

  • drugs and medicines
  • emergency medicine
  • healthcare improvement and patient safety
  • safety
  • unwanted effects / adverse reactions

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  • Contributors NGC and ATT were involved in patient management. JFHdlP and SA did the literature search and wrote the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.