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Primary small cell carcinoma of the vagina: a rare instance of prolonged survival
  1. Sri Harsha Kombathula1,
  2. Pragna Sagar Rapole1,
  3. Shyama Sudha Prem1 and
  4. Bhawana Badhe2
  1. 1 Radiation Oncology, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India
  2. 2 Pathology, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India
  1. Correspondence to Dr Sri Harsha Kombathula, drharsha2008{at}


Small cell carcinoma (SmCC) of the vagina is a rare and aggressive tumour. It comprises only 1% –2% of all gynaecological malignancies 85% of the patients with SmCC vagina die within a year of diagnosis. Here we report the case of a 65-year-old woman with stage III primary neuroendocrine carcinoma of vagina who was treated with chemoradiotherapy. The patient survived 1 year and 10 months after the initial presentation. SmCC of the vagina is very rare and despite being aggressive, the local disease can be controlled with a chemoradiation regimen.

  • gynecological cancer
  • radiotherapy

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  • Contributors SHK: corresponding author, gathered the information, drafted the manuscript. PSR: conceived the idea, reviewed the first draft. SSP: reviewed the first draft. BB: helped in the acquisition of data.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.