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Anti-Amphiphysin-associated limbic encephalitis in a 72-year-old patient with aortic angiosarcoma
  1. Tobias A Wagner-Altendorf1,
  2. Klaus-Peter Wandinger1,2,
  3. Alex Frydrychowicz3,
  4. Axel S Merseburger4 and
  5. Thomas F Münte1
  1. 1 Department of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany
  2. 2 Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Lübeck, Germany
  3. 3 Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany
  4. 4 Department of Urology, University Hospital Schleswig-Holstein, Lübeck, Germany
  1. Correspondence to Dr Tobias A Wagner-Altendorf, tobias.wagner-altendorf{at}


Paraneoplastic autoimmune encephalopathic syndromes have been described most often in association with small cell lung cancer or breast cancer, tumours of the ovaries, testes, lymphoma and thymoma. Antibodies associated with paraneoplastic encephalopathies are, among others, anti-Hu, anti-Ma2 and, in part, anti-N-methyl-D-aspartate(NMDA)-receptor antibodies. Here, we present the case of a 72-year-old patient hospitalised due to progressive cognitive decline and disorientation. Diagnostic workup revealed paraneoplastic anti-amphiphysin associated limbic encephalitis on the basis of an aortic angiosarcoma with metastases to kidney, muscle and bones. Highly aggressive chemotherapy as well as immunosuppressive therapy and cytoreductive laparoscopic nephrectomy were initiated. However, follow-up revealed further tumour progress and a worsening of neurological symptoms.

  • neurology
  • oncology
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  • Contributors Conception, design and drafting of the manuscript: Tobias A Wagner-Altendorf and Thomas F Münte. Critical revision of the article: Klaus-Peter Wandinger, Alex Frydrychowicz, Axel S Merseburger and Thomas F Münte. All authors approved the final version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

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