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CASE REPORT
Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival
  1. Yasmin Aghajan1,
  2. Denise M Malicki2,
  3. Michael L Levy3 and
  4. John Ross Crawford4
  1. 1 School of Medicine, UC San Diego, La Jolla, California, USA
  2. 2 Pathology, Rady Children’s Hospital University of California San Diego, San Diego, California, USA
  3. 3 Neurosurgery, University of California San Diego, San Diego, California, USA
  4. 4 Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA
  1. Correspondence to Dr John Ross Crawford, jrcrawford{at}ucsd.edu

Abstract

Paediatric high-grade gliomas, including glioblastoma and anaplastic astrocytoma, make up 8%–12% of paediatric central nervous system tumours1 and have poor prognosis, with 2-year survival less than 30%2 and overall survival less than 10%. The only known prognostic factors in this population include extent of resection and tumour histological grade. We present the case of a 9-year-old boy with disseminated anaplastic astrocytoma treated with subtotal resection, craniospinal radiation and temozolomide, with 8-year survival despite metastatic disease at presentation and subtotal resection. Next generation cancer gene panel sequencing revealed an usual pattern of 12 amplifications and four mutations not previously described.

  • neurooncology
  • cns cancer
  • paediatric oncology
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Footnotes

  • Contributors Dr YA was responsible for the design and writing of the case report. Dr DM was responsible for the design and writing of the case report. Dr ML was responsible for the design and writing of the case report. Dr JC was responsible for the design and writing of the case report. All authors approved of the submitted manuscript. All authors report no reported conflicts of interest.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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