Article Text

Download PDFPDF
Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis
  1. Akhila Arya P V1,
  2. Jayesh Kumar1,
  3. Dileep Unnikrishnan2 and
  4. Rishi Raj2
  1. 1 Department of Internal Medicine, Government Medical College, Kozhikode, Kerala, India
  2. 2 Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA
  1. Correspondence to Dr Dileep Unnikrishnan, drdileepunni{at}


A 24-year-old man with no significant medical history presented to the medical clinic with vomiting and giddiness for 2 days, loss of appetite for 1 month and progressive fatigability for the preceding 4 months. On examination, he was found to be hypotensive and was admitted to the hospital for work-up. Considering his abnormal labs and physical findings, he was worked up and was diagnosed with primary adrenal insufficiency. On further work-up for the aetiology of his Addison’s disease, he was found to have concurrent autoimmune thyroiditis and vitiligo. A final diagnosis of autoimmune polyglandular syndrome type 2 was made. The patient was started on hormone replacement therapy and reported improvement of symptoms on 3-month follow-up visit.

  • endocrinology
  • adrenal disorders
  • thyroid disease
  • immunology

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors AAPV, JK, DU and RR have directly contributed to the manuscript preparation of the case report or care of the patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note The authors certify that neither this manuscript nor one with substantially similar content under their authorship has been published or is being considered for publication elsewhere.

  • Patient consent for publication Obtained.