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CASE REPORT
Retinal and choroidal circulation determined by optical coherence tomography angiography in patient with amyloidosis
  1. Masami Tei,
  2. Ichiro Maruko,
  3. Eiko Uchimura and
  4. Tomohiro Iida
  1. Ophthalmology, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan
  1. Correspondence to Dr Ichiro Maruko, imaruko{at}twmu.ac.jp

Abstract

A 43-year-old woman who was diagnosed with the cryopyrine-associated periodic syndrome (CAPS) with severe renal failure and heart failure due to amyloid accumulation was examined by swept source optical cohernce tomography (OCT) (SS-OCT; DRI-OCT, Topcon, Tokyo, Japan) and optical coherence tomography angiography (OCTA) (RTVue XR Avanti, Optovue, Fremont, CA). Her best-corrected visual acuity was 20/40 OD and 20/25 OS. A hyporeflective band of about 100 µm thickness was seen just inferior to the retinal pigment epithelium in the cross-sectional SS-OCT images, but the deeper choroidal structures were clearly visible. In the OCTA images, the density of the retinal capillaries in the superficial and deep capillary plexus slabs were reduced, and no signals of the choroidal capillary slab was detected after removing the projection artefacts. The accumulation of amyloid can cause a reduction of both the retinal and choroidal capillary circulations although the circulation in the larger vessels are preserved.

  • retina
  • macula

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Footnotes

  • Contributors Designing and conducting of study: MT, IM. Data collection: MT, IM, EU. Analysis and interpretation of data: MT, IM, EU. Manuscript preparation and review: MT, IM, EU, TI. Approval of the manuscript: MT, IM, EU, TI.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

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