Article Text

Download PDFPDF
Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease
  1. Saki Manabe,
  2. Hidetaka Yanagi,
  3. Hideki Ozawa and
  4. Atsushi Takagi
  1. Division of General Internal Medicine, School of Medicine, Tokai University, Isehara, Japan
  1. Correspondence to Dr Saki Manabe, saki.manabe{at}


A 65-year-old Japanese woman with Parkinson’s disease, later diagnosed with Lewy body disease, presented with a 2-day history of systemic tremors. She also had fever without rigidity or creatine kinase (CK) elevation. She was diagnosed with sepsis caused by pyelonephritis with acute kidney injury and parkinsonism exacerbation. Although antibiotic and fluid therapy improved her pyuria and renal function, her fever and tremors persisted. On the fourth day, her symptoms worsened and resulted in cardiopulmonary arrest; however, quick resuscitation allowed the return of spontaneous circulation. Simultaneously, hyperthermia, altered consciousness, extrapyramidal symptoms, dysautonomia and CK elevation were noted. Thus, dantrolene administration was initiated with a tentative diagnosis of neuroleptic malignant syndrome (NMS). This caused her fever to subside, and her symptoms gradually improved. It was difficult to distinguish between parkinsonism exacerbation associated with sepsis and NMS. Physicians should consider NMS early on, even if the patient does not fulfil the diagnostic criteria.

  • primary care
  • intensive care
  • neurology
  • psychiatry
  • unwanted effects / adverse reactions
View Full Text

Statistics from


  • Contributors SM prepared the manuscript, and HY gave precise advice and edited the manuscript. HO and AT supervised. All authors have read and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.