Article Text

Solitary ascending colon ulcer diagnosed as gastrointestinal CMV disease
  1. Robert Case Jr1,
  2. Patrick Stoner2,
  3. Samuel Myrick3 and
  4. Ellen Zimmermann4
  1. 1 Department of Internal Medicine, University of Florida, Gainesville, Florida, USA
  2. 2 Department of Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
  3. 3 Florida Cancer Affiliates Ocala, Ocala, Florida, USA
  4. 4 Gastroenterology, University of Florida College of Medicine, Gainesville, Florida, USA
  1. Correspondence to Dr Robert Case Jr, racase42{at}


A 42-year-old woman with a history of cholangiocarcinoma on adjuvant chemotherapy with capecitabine presented with painless haematochezia. She was found to have an isolated twenty-five mm ulcer in the ascending colon. Biopsies of the ulceration demonstrated typical cytomegalovirus (CMV) inclusions and her peripheral blood CMV PCR was significantly elevated. This is an unusual case of a solitary proximal colon ulcer. Non-steroidal anti-inflammatory drugs, inflammatory bowel disease and malignancy, are the most frequent causes of isolated ulcers in the proximal colon. Gastrointestinal (GI) CMV disease most commonly causes CMV colitis and is considered rare outside of the transplant population and other severely immunosuppressed patient groups. Patients who have received chemotherapy may also be at risk for GI CMV disease. The diagnosis should be suspected in patients who present with haematochezia or watery diarrhoea within a broad window of time after receiving chemotherapy.

  • GI bleeding
  • Infection (gastroenterology)

Statistics from


  • Contributors RC: performed literature review, primary author of case report body. PS: review of case report with additional updates to content and editing of material. EZ: attending physician for patient while hospitalised, review of entire case report with addition of content and editing of grammar. SM: primary oncologist for patient described in the case. He was involved in providing information regarding follow-up and the clinical outcome for the patient in our case.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.