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Posterior reversible encephalopathy syndrome due to hypercalcaemia: a rare cause
  1. Nandakrishna Bolanthakodi,
  2. Sudha Vidyasagar,
  3. Muralidhar Varma and
  4. Avinash Holla
  1. Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  1. Correspondence to Dr Nandakrishna Bolanthakodi, nandaksb{at}


Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey et al in late 90’s, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.

We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism. She had seizures and visual defects on presentation which recovered completely with treatment of hypercalcemia.

  • hypertension
  • calcium and bone
  • epilepsy and seizures
  • neurological injury
  • unwanted effects / adverse reactions

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  • Patient consent for publication Obtained.

  • Contributors NB and AH were involved in case report writing, SV, MV and NB were involved actively in case management.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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