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Case report
Primary seminal vesicle adenocarcinoma: a lethal yet cryptic malignancy with review of literature
  1. Abhishek Bhat1,
  2. Indraneel Banerjee1,
  3. Oleksandr N Kryvenko2,3 and
  4. Ramgopal Satyanarayana1
  1. 1Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA
  2. 2Department of Pathology and Laboratory Medicine, University of Miami, Miami, Florida, USA
  3. 3Department of Pathology, Sylvester Comprehensive Cancer Center, Miami, Florida, USA
  1. Correspondence to Dr Abhishek Bhat; axb1722{at}


The rarity of primary seminal vesical adenocarcinoma (PSVA) coupled with mostly late and advanced presentation with high mortality makes it an unanticipated malignancy with poor prognosis. Although there has been sporadic reporting of cases, the dearth of literature makes standardised care a challenge. The detection has incorporated immunohistochemistry for establishing the site of origin as well as the differentiation of primary from metastatic cancer. Surgical management with seminal vesiculectomy continues to be the mainstay of treatment, but difficult anatomy and delayed intervention do lead to an increased chance of residual disease that may warrant further adjuvant chemoradiation. We present a case report where PSVA developed in a patient with Zinner syndrome—an observation that is extremely rare with a literature review of PSVA including the various aspects of management including contemporary diagnosis techniques.

  • urological cancer
  • urological surgery
  • urinary and genital tract disorders
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  • Twitter @drabhishekbhat, @ib_uro

  • Contributors AB is responsible for planning, conducting, reporting, conception and design, acquisition of data and analysis, preparing the drafts and finalisation of copy. Also responsible for consenting the patient for sending the case report to BMJ case reports. Responsible for all edits and revisions as recommended by reviewers. IB is responsible for planning, reporting, designing and acquisition of data. ONK is responsible for planning, conduct, reporting, conception and design of pathology section along with proof reading and finalisation. RS is responsible for planning, conduct, reporting, conception and design, acquisition of data, analysis and proof reading of final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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