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Case report
Tumour-induced osteomalacia due to an intra-abdominal mesenchymal tumour
  1. Brijesh Krishnappa1,
  2. Swati Ramteke Jadhav1,
  3. Anurag R Lila2 and
  4. Tushar R Bandgar1
  1. 1Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India
  2. 2Endocrinology, Seth GS Medical College, Mumbai, Maharashtra, India
  1. Correspondence to Dr Brijesh Krishnappa; brijeshpup{at}gmail.com

Abstract

A 50-year-man presented with debilitating lower-limb proximal muscle weakness and hip pain since 3 years. Investigations (serum calcium (8.9 mg/dL), serum phosphorus (1.5 mg/dL), serum albumin (40 g/L), parathyroid hormone (116 pg/mL (12.30 pmol/L)), 25(OH)D3 (25.2 ng/mL (63 nmol/L)) 1,25(OH)2 D3 (19 pg/mL (45.60 pmol/L)), tubular reabsorption of phosphate of 0.22 and elevated serum fibroblast growth factor 23 (FGF23) (387.7 RU/mL)) were consistent with tumour-induced osteomalacia (TIO). Localisation studies (68Ga DOTATATE positron emission tomography (PET)/CT and 18FDG-PET/CT) did not reveal any lesion. Re-evaluation after 2 and 5 years with 68Ga-DOTANOC PET/CT showed 2×1.4 cm progressively increasing rounded soft tissue enhancing mass close to splenic hilum (SUV max: 26.4). Tumour was resected by laparotomy. Both FGF23 (120 RU/mL on day 3) and serum phosphorus (2.5 mg/dL on day 10) normalised with significant clinical improvement after surgery. Histopathology revealed phosphaturic mesenchymal tumour. Here, we report the first case of intra-abdominal mesenchymal tumour causing TIO diagnosed by serial functional imaging.

  • calcium and bone
  • endocrine cancer
  • radiology
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Footnotes

  • Contributors TRB and ARL conceived of the presented idea. BK developed the theory and performed the computations. TRB and ARL encouraged SRJ to investigate and supervised the findings of this work. All authors discussed the results and contributed to the final manuscript. All the authors mentioned in the contributorship statement are considered as authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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