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Case report
Blue rubber bleb nevus: a rare cause of GI bleeding—review of management
  1. Mamoon Ur Rashid1,
  2. Muzammil Muhammad Khan2,
  3. Waqas Ullah3,
  4. Ishtiaq Hussain4 and
  5. Abu Hurairah5
  1. 1 Internal Medicine, AdventHealth Medical Group, Dade City, Florida, USA
  2. 2 Internal Medicine, Khyber Medical College, Peshawar, Pakistan
  3. 3 Internal Medicine, Abington Jefferson Health, Abington, Pennsylvania, USA
  4. 4 Internal Medicine, Mardan Medical Complex, Mardan, Pakistan
  5. 5 Gastroenterology, AdventHealth Medical Group, Apopka, Florida, USA
  1. Correspondence to Dr Waqas Ullah; waqasullah.dr{at}


Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital vascular anomaly syndrome characterised by multifocal venous vascular malformations. It involves skin, central nervous systems, liver, muscles and gastrointestinal (GI) tract resulting in intestinal haemorrhage and anaemia. Patients with BRBNS experience severe chronic anaemia without any diagnosis requiring multiple transfusions and hospitalisations. BRBNS has a propensity for severe life-threatening bleeding. Skin and GI tract are the most commonly affected organs.

  • dermatology
  • gastroenterology
  • cardiovascular medicine

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  • Contributors IH and MMK coordinated the data collection. MUR did the statistical analysis and wrote the manuscript. WU helped in reference arrangement and data mining. AH did the critical review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.