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Case report
Neurosarcoidosis presenting with a partial Claude syndrome
  1. Hao Meng Yip1,
  2. Kirtana Vallabhaneni1 and
  3. David Williams2
  1. 1 Nephrology, North Middlesex University Hospital NHS Trust, London, UK
  2. 2 Neurology, North Middlesex University Hospital NHS Trust, London, UK
  1. Correspondence to Dr Hao Meng Yip; meng.yip{at}


Neurosarcoidosis when encountered by neurologists most commonly presents as cranial neuropathy, peripheral mononeuropathy,polyneuropathy, myopathy, meningitis or myelopathy. There are limited reports in the current literature on the cases of neurosarcoidosis patients presenting with ischaemic stroke. We discuss a 52-year-old patient with a known previous history of cutaneous sarcoidosis presenting with an acute third nerve palsy, facial weakness and ataxia. His magnetic resonance imaging (MRI) brain demonstrated focal signal changes in the midbrain consistent with an acute ischaemic event in the region of his third nucleus, suggesting a partial Claude syndrome presentation. Cerebrospinal fluid (CSF) examination demonstrated an elevated angiotensin-converting enzyme (ACE) level. We discuss the difficulties associated with confirming a diagnosis for his presentation and consider distinctions in stroke in neurosarcoid and its management in comparison to more common causes.

  • neurology
  • stroke
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  • Contributors HMY and KV contributed equally in writing the manuscript. DW revised the manuscript. HMY, KV and DW provided clinical care for the patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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