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Case report
Rosai-Dorfman disease with cutaneous plaques and autoimmune haemolytic anemia
  1. Sweta Subhadarshani1,
  2. Tarun Kumar2,
  3. Sudheer Arava2 and
  4. Somesh Gupta1
  1. 1Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  2. 2Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Dr Somesh Gupta; someshgupta{at}hotmail.com

Abstract

Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a non-Langerhan cell histiocytosis which primarily involves lymph nodes. Extranodal involvement in the form of cutaneous plaques can occur and can pose a diagnostic challenge because of pleomorphic presentation and histopathological mimics. Rarely, systemic autoimmune involvement may complicate the disease process. We present a 28-year-old woman with slowly evolving scaly erythematous cutaneous plaques and fluctuating lymphadenopathy, associated with autoimmune haemolytic anaemia. The patient responded favourably to oral corticosteroids and acitretin with significant flattening of cutaneous plaques, reduction in size of neck nodes and improvement of anaemia.

  • dermatology
  • haematology (incl blood transfusion)
  • pathology
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Footnotes

  • Contributors SS: preparation of manuscript, editing. TK and SA: preparation of part of manuscript. SG: preparation and editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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