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Case report
Autoimmune progesterone dermatitis presenting as fixed drug eruption
  1. Nancy Bhardwaj,
  2. Rashmi Jindal and
  3. Payal Chauhan
  1. Dermatology, Himalayan Institute of Medical Sciences, Dehradun, India
  1. Correspondence to Dr Rashmi Jindal; rashmijindal98{at}


Autoimmune progesterone dermatitis (APD) is a rare disorder that presents as recurrent cyclical cutaneous eruptions during the premenstrual period when progesterone level is elevated. It does not have a specific cutaneous manifestation of its own and presents with a multitude of common cutaneous conditions, thus making it a diagnostic challenge. We describe the case of a young woman who presented with a hyperpigmented patch on her left thigh, over which she developed recurrent erythema, pain and itching, starting 2 days before her menstrual cycle and resolving within 2 days after menstruation. Intradermal progesterone sensitivity test was positive. Histopathology of hyperpigmented patch showed features of fixed drug eruption. A diagnosis of APD presenting as fixed drug eruption was made. She was treated with oral contraceptive pills with significant improvement. This case has been reported because of its rarity and to highlight the clinical implications this condition can pose if diagnosis is not sought timely.

  • dermatology
  • skin
  • immunology
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  • Contributors This is to state that NB and RJ contributed in planning and conception of this case series. They also contributed in diagnosis, patient care and management. PC was involved in conception and conduct of this case series. NB, RJ and PC have contributed in drafting of the manuscript and revisions with intellectual inputs and have approved the final version to be submitted for publication.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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