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Case report
Nivolumab-induced adrenalitis
  1. Iqra Iqbal1,
  2. Muhammad Atique Alam Khan1,
  3. Waqas Ullah1 and
  4. Dina Nabwani2
  1. 1Internal Medicine, Abington Jefferson Health, Abington, Pennsylvania, USA
  2. 2Internal Medicine, Damascus University, Damascus, Syrian Arab Republic
  1. Correspondence to Dr Waqas Ullah; waqasullah.dr{at}gmail.com

Abstract

Immune checkpoint inhibitors (ICIs) are an evolving class of drugs for the treatment of various cancers; for example, their use is recommended as a second-line chemotherapy for non-small cell lung cancer. With the expanding use of ICIs, we are discovering their unique side effects, called immune-related adverse events (irAEs), which can impair gastrointestinal, hepatic, dermatological, endocrine and other systems. Nivolumab is an ICI that blocks the human programmed death receptor-1 (PD-1) on T cells to prevent the interaction between the receptor, PD-1, and human programmed death ligand-1 expressed on tumour cells. Here, we report a case of a 65-year-old woman with recurrent lung adenocarcinoma who was treated with nivolumab and developed immune-related adrenalitis, which was managed with hydrocortisone and fludrocortisone. This case highlights the importance of understanding the irAEs of ICIs to allow prompt recognition and management of life-threatening complications of the treatment.

  • adrenal disorders
  • unwanted effects / adverse reactions
  • lung cancer (oncology)
  • chemotherapy
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Footnotes

  • Twitter @vakasullah

  • Contributors II wrote the main manuscript. MAAK organised the data and wrote the case discussion. WU took care of the patient in the hospital and helped with case writing. DN worked on the references and organised the material.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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