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Case report
Intracranial invasive mycosis mimicking hepatic encephalopathy in a patient with cirrhosis
  1. Akash Roy1,
  2. Nipun Verma1 and
  3. Chirag Kamal Ahuja2
  1. 1Hepatology, Post Graduate Institute of Medical Education and Research (PIGMER), Chandigarh, India
  2. 2Neuroradiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
  1. Correspondence to Dr Nipun Verma; nipun29j{at}


A 45-year-old man with alcohol-related decompensated cirrhosis presented with jaundice, fever, headache and altered sensorium. At presentation, he had tachycardia, disorientation to time and place, asterixis, icterus and upgoing plantar response. Investigations showed anaemia, thrombocytopenia, leucocytosis, hyperbilirubinemia and elevated arterial ammonia. Despite management with antihepatic coma measures and normalisation of ammonia, broad-spectrum antibiotics, 20% albumin, the patient worsened. On day 3, the patient developed generalised tonic–clonic seizure prompting mechanical ventilation. Examination showed right proptosis, chemosis and pupillary anisocoria. MRI brain showed multifocal infarcts in the right temporal lobe, right cerebellum and brainstem with inflammation in the right orbit, infratemporal fossa with right internal carotid artery thrombosis, and suspicious maxillary sinus thickening. Nasal scrapings showed aseptate fungal hyphae and serum galactomannan index was positive. Despite receiving liposomal amphotericin-B, patient had an unfavourable outcome. Intracranial invasive mycosis can mimic hepatic encephalopathy and is associated with high mortality in cirrhotics. A high index of suspicion, positive biomarkers and diagnostic radiology may provide the key to the diagnosis.

  • cirrhosis
  • neuroimaging
  • infectious diseases
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  • Contributors AR: manuscript writing. NV: patient management, critical revision. CKA: neuroimaging interpretation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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